-
Product Directory
Custom Product
-
Services Offered
Custom Capabilities
-
Sigma-Aldrich
Benzamidine hydrochloride hydrate
B6506 -
≥99%
DOWNLOAD MSDS (PDF)Synonym: Amidinobenzene hydrochloride, Benzamidinium chloride, Benzenecarboximidamide hydrochloride
CAS Number: 206752-36-5
Linear Formula: C6H5C(=NH)NH2 · HCl · xH2O
Molecular Weight: 156.61 (anhydrous basis)
Beilstein Registry Number: 3594959
EC Number: 216-795-4
MDL number: MFCD00066285
PubChem Substance ID: 24278275
Properties
| Related Categories | Core Bioreagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kallikrein tissue, |
| assay | ≥99% |
| mp | 86-88 °C(lit.) |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.
In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.
Peptidase inhibitor.
Packaging
5, 25, 100 g in glass btl
Preparation Note
Benzamidine HCl is soluble in water and alcohol. Solubility testing in water at a concentration of 50 mg/ml yields a clear solution with heating. Benzamidine HCl is sensitive to oxidation. It is recommended to prepare solutions fresh each time in degassed water prior to use. However, frozen aliquots stored under inert gas, to exclude air, may be stable for a short time. Insufficient information is available to assess the shelf-life of a frozen solution.
Price and Availability
Customers Also Purchased
Documents
Certificate of Analysis
Certificate of Origin
| B6506 - Product Information Sheet (78KB) |
| Structure Search |  |
| Similar Products |
Safety Information
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
References
Jeffcoate, S.L. and White, N., J. Clin. Endocrinol. Metab. 38, 155, (1974) Abstract
Deutscher, M.P Meth. Enzymol. 182, 83, (1990) Abstract
Jazwinski, S.M Meth. Enzymol. 182, 154, (1990) Abstract
Gegenheimer, P Meth. Enzymol. 182, 174, (1990) Abstract
Beil. 9,IV,898
FT-IR 2 (2), 3088:D / FT-IR 1 (2), 412:A / FT-NMR 1 (2), 1467:A / IR-Spectra (3), 1104:B / IR-Spectra (2), 963:B / NMR-Reference 2 (2), 383:B / RegBook 1 (2), 2087:A / Sigma FT-IR 1 (2), 301:D / Structure Index 1, 330:D:5 / Structure Index 1, 330:E:5
Printable Reviews
Share your experience with this product and how it worked in your specific application. We value your opinion and your colleagues will too!
Learn more at www.sigmaaldrich.com/reviews.
Technical Service:
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Bulk Ordering & Pricing:
Need larger quantities for your development, manufacturing or research applications?